The records of 200 multiple traumatized patients were reviewed retrospectively, in order to investigate the effects of time and methods of fracture fixation on morbidity an mortality. Early surgical fixation (ESF) of major fractures in the first 48 hours atler injury was perlormed to 103 patients, Iate surgical fixation (LSF) (atler 48 hours) was used in 57 patients, and 40 patients were treated conservatively differences between these three groups, according to the average age, modified injury severity scale score, hospital stay and major orthopaedic infection. However rates of adult respiratory distress syndrome (ARDS), fat embolism, and mortality were found to be 3.9 %, 1% and 1.9% in the ESF group , 8.8%, 10.5% and 7% in the LSF group, but 25%, 27.5% and 22.5% in the CT group, respectively. This rates obtained for the CT group were statistically higher, than that of the two surgically treated groups. Although the rates of the ESF group were much lower than that of the LSF group, only the difference for fat embolism was show to be statistically lower (p<0.05). As the result, the selected time and methods of fracture fixation were found to have an important effect on the prognosis of these patients. Since the lowest morbidity and mortality rates were observed in the ESF group, it was concluded that this method should be preferred in patients, tolerating anesthesia and surgery, for all major fractures, especially at lower exlremities in the first 24-48 hours.