Acta Orthopaedica et Traumatologica Turcica
Research Article

Comparison of systemic inflammatory responses of proximal femoral nail versus dynamic hip screw after treatment of patients with pertrochanteric fractures: A prospective comparative study


Department of Orthopaedic Surgery, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia


Department of Orthopaedic and Traumatology, University Clinical Center of Kosovo, Prishtina, Kosovo


School of Medicine, University of Gjakova “Fehmi Agani’’, Gjakove, Kosovo


School of Medicine, University of Prishtina "Hasan Prishtina", Prishtina, Kosovo

AOTT 2021; 55: 293-298
DOI: 10.5152/j.aott.2021.20193
Read: 206 Downloads: 72 Published: 17 August 2021

Objective: The aim of this study was to investigate the differences between the induction of early postoperative inflammatory response and muscle tissue injury biomarkers after treatment of pertrochanteric fractures by dynamic hip screw (DHS) or proximal femoral nail (PFN).

Methods: In this prospective comparative study, 40 patients with AO-Müller/Orthopaedic Trauma Association (AO/OTA) 31. A1–31.A2 pertrochanteric fractures were enrolled and allocated one of the two groups based on the treatment type: group DHS, (n =20,mean age = 78.4 ± 6.9 years) and group PFN (n = 20, mean age = 77.75 ± 7.0 years). Operation time was recorded in both groups. In each patient, circulating levels of high sensitivity interleukin-6 (hs-IL-6), C-reactive protein (CRP), and creatine kinase (CK), and erythrocyte sedimentation rate (ESR)weremeasured fromblood samples collected 1 hour preoperatively and 24 hours postoperatively.

Results: The operation time was slightly shorter in group PFN than in group DHS (51.9 ± 21.1 and 38 ± 15.2 min, respectively; P = 0.02). DHS and PFN both increased hs-IL-6 (143.81 ± 89.12 and 94.13 ± 67.14, respectively), CRP (98.84 ± 31.81 and 104.4 ± 31.80, respectively), and CK (400.8 ± 31.81 and 250.7 ± 31.80, respectively) 24 hours postoperatively. However, PFN compared to DHS resulted in a lesser increase from baseline to 24 hours postoperatively only in hs IL-6 (58.91 ± 59.02 vs 113.30 ± 76.24, respectively; P = 0.0016) and CK (163.6 ± 123.3 vs 310.0 ± 198.3, respectively; P < 0.0001).Moreover, there was a positive correlation of CK levels’ surgery time in DHS (r = 0.38, P = 0.0065) and PFN (r = 0.45, P = 0.0013). 

Conclusion: The results of this study have shown that PFN can induce a lower early postoperative inflammatory response and muscle tissue injury based on the assessment of hs-IL-6 and CK levels, compared to DHS in after the treatment patients pertrochanteric fractures.

Level of Evidence: Level II, Therapeutic Study

Cite this article as: Grezda K, Jelic M, Daci A, Bytyqi C, Kida Q. Comparison of systemic inflammatory responses of proximal femoral nail versus dynamic hip screwafter treatment of patients with pertrochanteric fractures: A prospective comparative study. Acta Orthop Traumatol Turc 2021; 55(4): 293–298.

ISSN 1017-995X EISSN 2589-1294